Sr. Scientist
AstraZeneca

Waltham, Illinois

This job has expired.


Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness cente, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Summary of the group:

This is a scientific job with responsibility for pharmacometrics (PMx) activities in the Virology and Immune Therapies/Neuroscience (V&I/NS) Therapy Area including population PK, PKPD, exposure-response, disease modelling, and simulations in all clinical development phases. With support from the V&I/NS Senior Director and the V&I/NS Therapy Area Head, the incumbent will be responsible for integrating and analysing internal and external data to support interpretation and decision making at both study level and project level.

The individual will drive the application of foundational and cutting-edge pharmacometrics techniques, in combination with business domain knowledge, to develop and apply advanced modelling to generate business and scientific insights. They will likely coordinate the creation, maintenance and/or improvement of advanced pharmacometric models for ongoing and ad hoc review and analysis. The individual will provide coaching, task management and support to junior staff and promote best practice across multiple domains, and/or stakeholder groups.

The position is based at the AstraZeneca state-of-the-art R&D campus in Gaithersburg, MD, USA.

Main Duties & Responsibilities:

  • Accountable for expert data integration, analysis, interpretation, and reporting of M&S results at the study level
  • Accountable for executing state-of-the-art M&S techniques with direct value for the project
  • Use of M&S to influence study designs and go/no go decisions
  • Development of drug-disease models to support projects within a specific disease domain
  • Contribute to regulatory documents and interactions (written)
  • Presentation of M&S results in internal and external forum
  • Contribute to internal initiatives to develop the pharmacometrics discipline including its processes
  • Participation in peer review of ongoing activities, reports and presentations
Compliance with Good Clinical Practice (GCP) regulations as well as internal/external guidance's

Education & Experience Requirements
  • PhD degree preferred or equivalent (M.Sc./Pharm.D.) with relevant experience required
  • Relevant regulatory experience (written)
  • Training and experience with PK and statistical software (NonMem, R, Stan, Winbugs ,SAS, Monolix , Phoenix, WinNonlin)

Essential for Sr. Scientist
  • Demonstrated expertise in pharmacometrics, including PK, PKPD and/or statistics
  • Strong quantitative skills (e.g. experience in population modelling, statistics, systems and translational pharmacology modelling).
  • Expert knowledge of pharmacokinetics and Model-Informed Drug Development (MIDD)
  • For a PhD, demonstrated broad translational and clinical development expertise and experience exemplified by 1-3 years of drug development experience, with emphasis on Clinical Pharmacometrics
  • For M.Sc./Pharm.D. demonstrated broad translational and clinical development expertise and experience exemplified by >8 years of drug development experience, with emphasis on Clinical Pharmacometrics
  • Demonstrated ability to identify, develop and execute Pharmacometrics activities at a project level
  • Good oral and written communication skills
  • Good knowledge of global regulatory, compliance, processes, standards and issues specific to clinical pharmacology

Essential for Associate Director
  • Demonstrated expertise in pharmacometrics, including PK, PKPD and/or statistics
  • Strong quantitative skills (e.g. experience in population modelling, statistics, systems and translational pharmacology modelling).
  • Expert knowledge of pharmacokinetics and Model-Informed Drug Development (MIDD)
  • For a PhD, demonstrated broad translational and clinical development expertise and experience exemplified by >5 years of drug development experience, with emphasis on Clinical Pharmacometrics
  • For M.Sc./Pharm.D. demonstrated broad translational and clinical development expertise and experience exemplified by >13 years of drug development experience, with emphasis on Clinical Pharmacometrics
  • Demonstrated ability to identify, develop and execute Pharmacometrics activities at a project level
  • Good oral and written communication skills
  • Good knowledge of global regulatory, compliance, processes, standards and issues specific to clinical pharmacology

Desirable
  • Scientific publishing in the field of pharmacometrics
  • Early or late phase clinical development experience/awareness
  • Knowledge in pharmacology, drug targets and core disease areas

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next!

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.


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